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We tested the hypothesis that an anticardiolipin antibody(aCL)titer of>10 IgG phospholipid(GPL)at the time of an index ischemic stroke is associated with an increased risk of subsequent thrombo-occlusive events or death. First-time ischemic stroke patients from the Antiphospholipid Antibodies and Stroke Study Group's Prevalence Study were followed prospectively for a median time of 24 months for any thrombo-occlusive event or death.There was not significant difference for the endpoint of stroke,death,myocardial infarction,transient ischemic attack,deep venous thrombosis,pulmonary embolus,or arterial embolus between the aCL positive and negative patients.Although a single aCL value of>10 GPL at the time of an initial ischemic stroke is a significant independent risk factor for stroke,when adjusted for other stroke risk factors in our study population,aCL positivity did not confer a significant increased risk for subsequent thrombo-occlusive events or death. |
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